The origins of the Gambino crime family can be traced back to the faction of newly transplanted mafiosi from Palermo, Sicily who were originally led by Ignazio Lupo. 11 List of murders committed/ordered by the Gambino crime family.Beginning in 2015, the family was headed by Frank Cali until his assassination outside his Staten Island home on March 13, 2019. Gravano's cooperation brought down Gotti, along with most of the top members of the Gambino family. Gotti's downfall came in 1992, when his underboss Salvatore 'Sammy the Bull' Gravano cooperated with the FBI. Castellano infuriated upstart capo John Gotti, who orchestrated Castellano's murder in 1985. The family's fortunes grew through 1976, when Gambino appointed his brother-in-law Paul Castellano as boss upon his death. Gambino partnered with Meyer Lansky to control gambling interests in Cuba. Experts believe that Anastasia's underboss Carlo Gambino helped orchestrate the hit to take over the family. The rise of what was the most powerful crime family in America for a time began in 1957, when Anastasia was assassinated while sitting in a barber chair at the Park Sheraton Hotel in Manhattan. was smashed in the late 1940s, and took over his family in 1951-by all accounts, after murdering the family's founder Vincent Mangano-which was then recognized as the Anastasia crime family.

He remained in power even after Murder, Inc. Its most prominent member during this time was its underboss Albert Anastasia, who rose to infamy as the operating head of the underworld's enforcement arm, Murder, Inc. For most of the next quarter-century, it was a minor player in organized crime. The family was one of the five families that were founded in New York after the Castellammarese War of 1931. Its illicit activities include labor and construction racketeering, gambling, loansharking, extortion, money laundering, prostitution, fraud, hijacking, and fencing.

The group's operations extend from New York and the eastern seaboard to California.

The group, which went through five bosses between 19, is named after Carlo Gambino, boss of the family at the time of the McClellan hearings in 1963, when the structure of organized crime first gained public attention. The Gambino crime family (pronounced ) is an Italian-American Mafia crime family and one of the ' Five Families' that dominate organized crime activities in New York City, United States, within the nationwide criminal phenomenon known as the American Mafia. Various gangs in New York City, including their allies Inzerillo and the Sicilian Mafia in general Racketeering, extortion, fraud, illegal gambling, money laundering, murder, robbery, drug trafficking, fencing, truck hijacking, loan sharking, prostitution and pornography Italians as ' made men' and other ethnicities as associatesġ50–200 made members and 1,500–2,000 associates (2004) Primarily New York City, with additional territory in Long Island, New Jersey, Western Connecticut, Baltimore, South Florida, Tampa, Atlanta, Los Angeles, Las Vegas and Palermo, Sicily Carlo Gambino, the Gambino crime family's namesake

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